PE-22-28 (Mini-Spadin) blocks TREK-1 potassium channels with ~100-fold greater potency than its parent compound, demonstrating BDNF upregulation, rapid neurogenesis within 4 days, and cognitive benefits in stroke models (Djillani et al., 2017 in Frontiers in Pharmacology)
Arsenic and oxidative stress: an overview
Cell migration
While Vitamin B12 tablets are readily available, easy to use (you just pop it in your mouth!), and cheaper, the rate at which the vitamin absorbs in tablet form is relatively slow
This drug combination is considered standard treatment for PD symptoms such as tremor, muscle stiffness, and slowness of movement
For instance, a patients follow-up visit for B12 re-evaluation is not recorded, causing issues with continuity of care