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Kuka et al

A common crossroad is cellular senescence, a state of indefinite cessation of the cell cycle, triggered by mitotic stress, DNA damage, telomere erosion, mitochondrial dysfunction, oxidative stress, inflammation, mechanical stress and oncogenic activation [187]

"Perhaps doses that achieve modest weight loss but robust anti-inflammatory and vascular benefits might be appropriate for some indications, while maximum-tolerated doses remain appropriate for obesity," says Nadolsky

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