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Butyrate is the preferred fuel for colonocytes the cells that line and protect the gut

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doi:10.1055/a-1804-6601

Indeed, HGF protects BBB disruption after microsphere embolism-induced sustained cerebral ischemia by avoiding the inhibition of Bcl-2 (Date et al., 2006), thus decreasing apoptosis, and by reducing the expression of occludin and zonula occludens (ZO)-1, which are tight junction proteins, in cerebrovascular endothelial cells (Takeo et al., 2008)

While none of these are totally representative of the disease, all are useful and competent approximations of its underlying mechanisms