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Kushner, R

2023: Tirezepatide (Zepbound) receives FDA approval for weight loss

The hormones that decline during this transition, primarily estrogen and progesterone, are not merely reproductive signals

This is particularly powerful in women with PCOS, perimenopausal weight gain, or metabolic sluggishnesswhere balancing hormones and blood sugar is key

This results in the activation of mast cells and the release of inflammatory mediators, including histamine, leukotrienes and others, which can manifest as pruritus, urticaria, angioedema, bronchospasm, vomiting and hypotension

Over time, many people build healthier eating patterns naturally