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(13) Additionally, GLP-1 signaling may help suppress pro-inflammatory pathways, reducing the chronic low-grade inflammation associated with both obesity and bone loss

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Participants randomized to retatrutide initiated treatment with 2 mg once weekly and increased the dose in a step-wise approach every four weeks until reaching the target dose of 9 mg (via steps at 2 mg, 4 mg and 6 mg) or 12 mg (via steps at 2 mg, 4 mg, 6 mg and 9 mg)

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