All GLP-1 receptor agonists are safe in terms of cardiovascular outcomes, and liraglutide, semaglutide, albiglutide, dulaglutide and efpeglenatide have been shown to have cardiovascular benefits in cardiovascular outcomes trials [22]
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Clinical trials showed an average weight loss of 11.2% over 16 months at the highest dose
In a 2024 literature review published in the Journal of the American Pharmacists Association that assessed six clinical trials , researchers found that tirzepatide had a greater impact on absorption of oral hormonal contraceptives compared with other GLP-1s
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This included 12 trials focused on SGLT2 inhibitors, 10 focused on GLP-1 receptor agonists and one that evaluated pioglitazone