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A study demonstrated that naringin inhibits the mRNA expression of inflammatory cytokines, and MMPs, including MMP-1, MMP-3, MMP-9, and MMP-13, and promotes apoptosis in RA-FLS via PI3K/Akt and MAPK/ERK signaling pathways, as shown in Figure 2 [72]

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[DOI: 10.1016/S0046-8177(03)00367-8] [DOI] [PMC free article] [PubMed] [Google Scholar] 28.Nicholls JM, Poon LLM, Lee KC, Ng WF, Lai ST, Leung CY, Chu CM, Hui PK, Mak KL, Lim W, Yan KW, Chan KH, Tsang NC, Guan Y, Yuen KY, Peiris JSM