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Some major Medicare Advantage insurers have begun using a prior authorization process to make sure that theyre only covering GLP-1 drugs for patients who have been diagnosed with Type 2 diabetes

It has been shown that in patients with type 2 diabetes mellitus (T2DM) the response to the incretin effect is altered as a result of a severe defect in the sensitivity for GIP in the cells [4] and a reduction in food-induced GLP-1 secretion [5, 6]

Researchers have been able to show, however, that GLP-1 binds receptors in multiple nuclei within the hypothalamus

Zhang, L., Zhang, L., Li, L

Uchiyama S, Sada Y, Mihara S, Sasaki Y, Sone M, Tanaka Y