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doi:10.2147/CCID.S128339

Since weve touched on chromatography for peptide analysis, its worth noting that peptides are prone to adsorption onto surfaces during analysis (often due to ionic or dipoledipole interactions with metals in the LC flow path), reducing sensitivity and compromising the accurate quantification of low-level impurities

This increased binding may well be attributed to an increased surface area of the microspheres compared to homogenates, but further experiments would be needed to test this hypothesis