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Introduction Spermatogenesis is an extremely active replicative process capable of generating approximately 1,000 sperm a second

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Accumulation of oxidative damage is considered to be one of the key mechanisms of aging.[55-57] Drosophila flies having 75% reduction in SOD activity, showed accelerated loss of olfactory behavior on ageing.[58] It has been suggested that novel SOD mimetics may be useful in attenuating aging-induced cognitive impairments and other aspects of physiological decline with aging.[59] SOD and rheumatoid arthritis Rheumatoid arthritis is a systemic disease and is characterized by a chronic inflammation reaction in the synovium of joints, leading to degeneration of cartilage and erosion of juxta-articular bone

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In: Brittain HG (ed) Profiles of drug substances, excipients and related methodology