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21 The top 10% of proteins within these networks were scored for network topology (connectivity and bottleneck) and used as markers of essential pathway functions, 22, 23 which were identified using the Reactome algorithm 24 plug-in for Cytoscape 2.8.2 25 (Supplementary Figure S2)

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The day-to-day variability in oral absorption was reduced by frequent dosing and the long half-life of semaglutide, leading to stable steady-state concentrations for oral semaglutide