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S-adenosylmethionine acts as a universal methyl donor for several reactions, being the major biological methylating agent (Brosnan et al., 2007)

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If confirmed in prospective studies, GLP-1RAs could represent the first medical therapy demonstrated to reduce rupture risk in observational data, offering a novel treatment option for patients with unruptured aneurysms who are not ideal surgical candidates due to smaller aneurysm size, older age, high surgical risk, or patient preference