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Alterations in calcium homeostasis can lead to mitochondrial swelling (Mller et al., 2011), resulting in the leakage of Ca 2+ ions from mitochondria

However, maturation of erythrocytes and conversion of erythroblasts to mature erythrocytes during erythropoiesis is accompanied by enucleation and organelle clearance [32]

Proliferating cells thus require access to free cysteine to deal with oxidative stress