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Rapid weight loss can signal energy deficiency to the hypothalamus, suppressing gonadotropin-releasing hormone (GnRH) and subsequently reducing luteinising hormone (LH) and follicle-stimulating hormone (FSH)

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There are currently no approved orally-administered GLP-1 agonists on the market for the treatment of obesity, said Jesper Hiland, Senior Strategic Advisor for Rani Therapeutics and former executive at Novo Nordisk

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