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This action decreases the formation of cyclic guanosine monophosphate (cGMP), a mediator of bronchoconstriction

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Some of the released molecules, referred to as damage-associated molecular patterns (DAMPs) like heme and its derivatives, ATP, heat shock protein (HSP70), or interleukin-33 (IL-33), are capable of triggering the immune response, amplifying inflammation [62, 63]