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Not only is there a lack of dopamine to contend with, but those who have been using opioids for an extended time have not focused on other important aspects of their health

Some, but not all, DPP-4 inhibitors have been associated with severe joint pain (92, 93)

Glossary GLP-1 RA (GLP-1 receptor agonist): a medicine class that mimics the gut hormone GLP-1 to improve insulin release, reduce appetite, and slow digestion GIP: a second gut hormone

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Providing treatment without understanding whats going on beneath the surface can do more harm than good

If you have been relying primarily on the medication for appetite control without building dietary and exercise habits, this is where that gap becomes apparent