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During treatment, these needles penetrate the stratum corneum, creating micro-conduits (small holes) without causing harm to the epidermis

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Rangroo Thrane V, Thrane AS, Wang F, Cotrina ML, Smith NA, Chen M, Xu Q, Kang N, Fujita T, Nagelhus EA, Nedergaard M (2013) Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering

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