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However, factors like aging, environmental stressors, and poor diet can put a heavy load on this system
Endocrine 68, 518525
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A protocol of alternate-day fasting (ADF, 24 months) in rats was able to reduce oxidative stress (assessed by the increased level of glutathione) and decrease inflammatory status in the heart during aging similar to young animals (Castello et al., )
For older children or young adults, this may result in a lower daily dose of NTBC than using the standard dosage of 1 mg/kg body weight that is recommended for infants
If diet and exercise alone were sufficient, obesity rates would likely be very different today
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