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The ratio of the two different types of melanin found in skin, black-brown colored eumelanin and yellow-red pheomelanin, determines the skin colour

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This ovoprotective effect is suggested to be mediated through activation of different SIRT1-mediated protective signaling pathways that remodel ovarian redox status, inflammation, and apoptosis, which may strengthen the potential role of SP and L-car as a chemotherapy adjuvant, reducing the negative health effects of early menopause after cancer therapy

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This effect is mediated by modulating the expression of the anti-apoptotic protein B-cell lymphoma Extra Large (Bcl-XL) and the pro-apoptotic protein Bax, ultimately resulting in the programmed cell death of tumor cells via the cascade activation of the caspase-9/caspase-3 protease system (Zeng et al., 2025)