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We did not find a significant non-linear relationship between dose (g/day) (coefficients = 1.72, p = 0.154) and changes in FBG, but we found a significant non-linear relationship (coefficients = 7.45, p = 0.020) between duration of intervention and changes in FBG, It seems that the effective duration for decreasing of FBG is 50 weeks (Figures 4A, 5A)

Hernndez C, et al

We would consider supplements such as methyl-folate and methyl B12, the active forms of B vitamins