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If that occurred, then -glutamyl cysteine, the final substrate of the glutathione synthase reaction (Figure 2, reaction 5), would be shunted into the dotted line pathway shown in Figure 2 instead of synthesis of glutathione

[177], including twenty-two RCTs involving 1377 patients, a poor performance was observed for metformin when compared to other antidiabetic drugs such as the GLP-1 receptor agonist for hepatic fat content, the MASLD activity score, ALT, AST, GGT, and body weight

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