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Drugs that usually cannot enter the CNS may become therapeutically beneficial by IN administration, as they bypass the BBB at significantly lower doses, with a subsequent decrease in adverse effects [9]
Indirectly, significant weight loss may not only diminish obesity-induced inflammation, but it also reduces obesity-related mechanical constraints on the diaphragm and chest wall, improves expiratory reserve volume (ERV) on pulmonary function testing, and reduce restrictive physiology that can be observed in individuals that are obese and have asthma
