B12 is safe on its own, but a few conditions call for extra care, which is why a provider reviews your history before treatment: Leber's hereditary optic neuropathy, a rare inherited eye condition, where certain forms of B12 may be a concern for the optic nerve
As for frequency, most patients receive Lipo-B injections about once a week for best results
For subcutaneous injections, a U-100 insulin syringe (typically 0.5mL or 1mL) with a fine needle (29-31 gauge) is standard
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