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These are associations rather than proof that altering NNMT activity reverses metabolic changes, but they motivate continued research into NNMT inhibitors in metabolic models

Additionally, monitoring symptoms related to vitamin B12 deficiency, such as fatigue, weakness, and neurological changes, can help assess the overall effectiveness of treatment and guide further management strategies

Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen may interfere with healing processes at higher doses or with prolonged use