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Currently preferred second agents are anti-angiogenic agents, such as angiostatin, endostatin, vasculostatin, canstatin and maspin
More recently, the SELECT trial confirmed cardiovascular benefits of Wegovy in patients with overweight/obesity and established cardiovascular disease without diabetes, leading to its 2024 FDA indication for cardiovascular risk reduction in this population
GLP-1/glucagon co-agonists: cotadutide and pemvidutide Cotadutide, a GLP-1/glucagon receptor dual agonist with 5:1 potency ratio, improved multiple hepatic parameters in phase 2 trials
The Takeaway You dont need extreme diets or drastic measures to support GLP-1
(This shared mechanism also explains why substances like fentanyl are so addictive.) GLP-1 receptors arent just located in the gut and pancreas
Doing so protects themselves as well as their friends and family
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