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The consequent increased generation of ROS and reactive aldehydic derivatives and the downregulation of genes for antioxidant enzymes induce an altered intracellular redox status causing oxidative stress and cell death, via ATP, NAD, and -glutamyl-cysteinyl-glycine (glutathione (GSH)) depletion [4]

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"The alcoholic ferment of yeast-juice Part II.--The coferment of yeast-juice"