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It has been evident that diminished NADPH causes failure to replenish endogenous antioxidants such as GSH, which weakens the ROS scavenging, favoring oxidative stress, and AD development [183]

F.et al (2016)

The Antioxidant Power of Glutathione As one of the most powerful antioxidants, glutathione helps protect cells from damage caused by free radicals and oxidative stress

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W., Mhaidat, N

Hypertriglyceridemia and hyperinsulinemia are potent inducers of endothelin-1 release in humans