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Microparticles Mediate the Intercellular Regulation of microRNA-503 and Proline-Rich Tyrosine Kinase 2 to Alter the Migration and Invasion Capacity of Breast Cancer Cells

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( a ) The expression of AHR or NRF2 in MCF-7 and U2OS cells targeted AHR and NRF2 by CRISPR/Cas9 was analyzed by Western blot

Although redox changes did not alter enzyme activity in vitro , it is possible that formation of the disulfide in the GCL from proteobacteria may alter the stability and/or half-life of the protein in vivo