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To elucidate the contribution of gpoA in the H 2 O 2 detoxification system of S

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3.5 Multi-organ damage from inflammation and metabolic dysregulation 3.5.1 Cardiovascular system Chronic inflammation promotes atherosclerosis and myocardial fibrosis by driving macrophage infiltration and releasing pro-inflammatory cytokines (TNF-, IL-6, MCP-1), which, in turn, destabilize plaques and contribute to heart failure through TGF--driven fibrosis Figure 3 (115)