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GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

Lipoic acid biosynthesis defects

The decrease of SCFAs can lead to intestinal inflammation and the loss of nutrition The most abundant short-chain fatty acids (SCFAs) in the human colon are acetate, propionate, and butyrate, can supply energy to cells in the colon, possess anti-inflammatory properties, and protect epithelial barrier integrity [138,139,140]

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This condition involves lingering symptoms that persist long after the initial infection has cleared up