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Increased CaMKK2 activity in the brain leads to CaMK4 activation and increased expression of BDNF, which in mice is indispensable for the anti-manic actions of lithium [45, 49]

Schopf, L

2010;60:e1217

Kaempferol reduces ROS generation by upregulating HO-1, protecting melanogenic enzymes and enhancing the MITF pathway, essential for melanin synthesis 143

A single exposure of doxorubicin between 0 and 50 M, yields minimal cytosolic GSH depletion (2.5% maximum decrease), which recovers within the prescribed time-span (Fig