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Why IGF-1 LR3 is more potent than native IGF-1 Native IGF-1 is largely sequestered in circulation by IGF binding proteins (IGFBPs) a family of six proteins that escort IGF-1 around the body and limit how much is free to engage receptors

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10.1038/s41591-025-03984-1 Nat Med

The preclinical case is extraordinary

If a provider tells you a for-sure timeline, you need to be cautious because the actual results vary from person to person based on the injury, overall rehabilitation plan, and individual healing response

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