Supplementary Data 1 (download ZIP Atomic coordinates for starting, ending and selected time-points of MD simulations
Consistent with the DM2AD comorbidity network, the highest-ranking drugs also ranked among the top drugs in the MCI pathway network, with metformin being the second-highest-ranked drug
While moderate weight reduction may yield metabolic benefits, rapid or sustained weight loss is frequently associated with decreased bone mineral density, deterioration of bone microarchitecture, and heightened fracture risk
Stress-induced chondrocyte senescence and OA may be the result of an increase in ROS generation in cartilage, which may be stimulated by damaging mechanical load (Yamazaki et al., 2003)
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