It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile
By this point, users typically see: 8-15 pounds fat loss (highly variable based on starting point, diet, and training) Significant improvement in body composition Reduced waist circumference (often 2-4 inches) Better muscle definition Improved energy and recovery Enhanced metabolic efficiency (easier to maintain leanness) The fat loss is real and maintainable
If vitamin B12 deficiency is not treated with a vitamin B12 supplement, then anemia, intestinal problems, and irreversible nerve damage may occur
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Some conditions require the full protocol duration for complete resolution
doi:10.1016/s0140-6736(78)92379-6
