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2025 Jul 12;406(10499):149-162

doi: 10.1212/WNL.0b013e3182a8236e 69 RamaniA.MllerL.OstermannP

Large meta-analysis (2,375 patients): An analysis across 26 trials of 2,375 patients with MASLD or MASH found that silymarin therapy reduced total cholesterol and LDL, raised HDL, reduced liver enzymes associated with liver injury, and improved measures of liver fat and biopsy-measured changes [24]

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In 2022, excess body weight (overweight and obesity) affected approximately 2.5 billion adults, with as many as 890 million suffering from obesity (relative to 1990 figures, the number of obese people grew by 684 million)

In addition to stimulated release in response to food intake, OXM exhibits diurnal variation in its concentration in the blood with highest levels detected in the evening and lowest levels in the morning