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Statements Author contributions LL: writing-original draft

MIC 90 was a concentration of 2.5 mg/ml of vitamin C and MIC 50 was a concentration of 1.25 mg/ml of vitamin C

Endothelial function improved with lower hsCRP and higher adiponectin

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

10.1021/acsnano.2c06629 215 ZhaoY.WangQ.ZhuJ.CaiJ.FengX.SongQ.et al (2024)

Conclusion Our findings highlight multiple mechanisms by which metformin-induced formation of reactive oxygen species may contribute to its efficacy in prostate cancer treatment, including promotion of oxidative stress, Nrf2 activation, and modulation of redox-related pathways, leading to its anti-survival action