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High blood glucose levels can trigger oxidative stress (OS), a state of imbalance between oxidation and the antioxidant defence system in the body []
doi: 10.1093/brain/awp296 169 PfefferG.BurkeA.Yu-Wai-ManP.CompstonD
Our findings suggest that GSH depletion induces ferroptosis, autophagy, and SIPS
Bottom line: MTHFR doesnt cause these conditions it can, however, tilt the terrain and thats actionable when we combine genetics with labs and clinical context
Intermediate progenitor cohorts differentially generate cortical layers and require Tbr2 for timely acquisition of neuronal subtype identity
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