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Insurance and Retail Options Insurance-covered GLP-1 therapy often comes with restrictions: prior authorization delays, step therapy requirements (forcing cheaper medications first), specialty pharmacy markups, and copays ranging from $50 to $500+ per month depending on your plan's tier

Additionally, some patients experience nausea, vomiting and digestive upset, which can contribute to feelings of tiredness

Tirzepatide is currently marketed as Zepbound for weight loss and obstructive sleep apnea in the U.S

Oral semaglutide increases levothyroxine exposure, so thyroid function should be monitored in patients taking both medications

doi: 10.1002/14651858.CD003312

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