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In an analysis of administrative claims data from the OptumLabs Data Warehouse published in JAMA OtolaryngologyHead & Neck Surgery , researchers found the absolute risk for thyroid cancer with GLP-1 medication use was low, with less than 70 adults of 41,112 of those initiating GLP-1 therapy developing thyroid cancer

The trials employed randomised, placebo-controlled designs with single ascending dose (SAD) and multiple ascending dose (MAD) protocols