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doi: 10.1158/1940-6207.CAPR-17-0268 77 CipollaBGMandronELefortJMCoadouYDella NegraECorbelLet al

Research has characterised MT-IIs anorectic effects as MC4R-mediated through hypothalamic PVN and arcuate nucleus mechanisms , documenting food intake suppression kinetics, NPY/AgRP pathway suppression, and melanocortin pathway activation markers in hypothalamic tissue following MT-II treatment

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