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The logic is straightforward: if you sleep through the initial wave of side effects, they bother you less

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10.1038/s41392-021-00701-5 83 ZhangT.ChaboryE.BritanA.GrignardE.PitiotO.SaezF.et al (2008)

That meal causes a much bigger, longer LPS response Your immune system burns a ton of energy fighting that response, which is why you feel sluggish and sleepy after bad meals LPS also binds to LDL particles, makes them harder for the liver to recycle, and they get stuck in artery walls Macrophages arrive thinking it is a bacterial invader

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Following an additional 1 h of stirring at 25 C, Ru(II)-OH (50 mg) was introduced into the reaction system