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Anything that irritates these nerves or the diaphragm itself can trigger the hiccup reflex. In the context of GLP-1 medications, the physical expansion of the stomach or the presence of excess gas can put pressure on the diaphragm

Immunology 135(1):18 Morsy MA, Fouad AA (2008) Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats

Dickinson, D.A., et al., Human glutamate cysteine ligase gene regulation through the electrophile response element

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Using conservative doses for reasonable durations with breaks between cycles represents a prudent approach to risk management