In June 2021, Huadong Medicine, a pharmaceutical firm based in Hangzhou, applied to Chinas State Intellectual Property Office to invalidate the patent
3) is another TLR family member upregulated in MASLD and lipopolysaccharide (LPS), ROS, HMGB1 and various damage-associated molecular patterns can bind to TLR4 in KCs to promote TNF-, IL-1, IL-6 and interferon- (IFN-) production of various pro-inflammatory cytokines, thereby contributing to hepatic inflammation and the progression of MASLD (54)
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Case Overview Clinical studies and drug labeling from the U.S