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Since it is a naturally occurring peptide already present in the body, it tends to be well tolerated by most users

Free Radicals in the Physiological Control of Cell Function

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The unbalanced regulation of the glutathione synthesis coupled with the rapid and steady increase of glutathione abundance in the wheat tissue of the infested resistant plants suggested that the -glutamylcysteine synthetase might be either inhibited by a negative feedback from GSH, or it is not the rate-limiting enzyme in the glutathione synthetic pathway in wheat plants under our experimental conditions

Based on these results, it can be concluded that low concentrations of MB (less than 2.5 M) neither irritate nor color skin and are therefore safe for long-term use