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Short-acting agents, such as exenatide and lixisenatide, exert pronounced meal-time fullness primarily through delayed gastric emptying, while long-acting formulations including liraglutide, dulaglutide, and semaglutide sustain a more persistent satiety tone via direct activation of brain receptors

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doi:10.1016/S0140-6736(23)01053-X 3

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Addressing the lack of several important hormones outweighed the potential risks of taking medications off-label

It is noteworthy that long-term HFD consumption may differentially regulate NF-B activity in hepatocytes (inhibition) and Kupffer cells (activation by lipopolysaccharide)