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The work leading to this publication has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement n115317 (DIRECT), resources of which are composed of financial contribution from the European Unions Seventh Framework Programme (FP7/20072013) and EFPIA companies in-kind contribution

10 Ongoing trials are currently studying semaglutide and tirzepatide for alcohol use disorder, semaglutide for opioid use and cannabis use disorder, liraglutide for opioid use disorder, and semaglutide and exenatide to achieve smoking cessation

The physiological basis of this approach centres on metabolic switching

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To use, insert suppositories vaginally or rectally as needed