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Protein intake and strength training have the strongest evidence for preserving muscle and improving body composition during weight loss

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Studies in animal models with gut microbiota depletion have shown increased plasma tryptophan, elevated brain serotonin concentrations, and reduced kynurenine pathway activity, all of which normalize following microbiota restoration (229231)

In the UK, semaglutide is available as Ozempic (for diabetes) and Wegovy (for weight management), while liraglutide is available as Victoza (for diabetes) and Saxenda (for weight management)