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While oral supplements are available, B12 injections are often considered more effective because they deliver the vitamin directly into the bloodstream for improved absorption

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These effects seem to be resolved in surgically treated patients, where a normalisation of this metabolic shift is observed (144)

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This process mainly relies on the active targeting mechanism: by modifying specific ligands on the surface of the nanoparticles, they can be recognized and internalized by target cells when flowing through the liver [178]