Liraglutide (Victoza, Saxenda) Blood sugar changes Headache Heartburn Constipation Vomiting Stomach pain Increased feelings of depression Mood changes Phentermine-Topiramate (Qsymia) Changes in taste Tingling, itching, burning, or prickling in your extremities Dry mouth Trouble staying focused Irritability Dizziness Constipation Numbness Headache Naltrexone-Bupropion (Contrave) Orlistat (Xenical) Fatty stools Frequent bowel movements Gassiness Inability to hold in stool Setmelanotide (Imcivree) Are Weight Loss Medications Right for You
Other Serious Risks Intestinal Blockage (Ileus) Added to Label: September 2023 Symptoms: Severe abdominal pain, inability to pass gas or stool, severe bloating, vomiting Risk: Can require emergency surgery to correct Pancreatitis Added to Label: January 2025 Symptoms: Severe upper abdominal pain, nausea, vomiting, fever Risk: Necrotizing pancreatitis can be life-threatening Kidney Injuries Added to Label: January 2025 Cause: Often related to severe dehydration from persistent vomiting Risk: Acute kidney injury requiring hospitalization Gallbladder Disease Research: 2023 JAMA study linked higher doses to increased risk Symptoms: Severe pain in upper right abdomen, nausea, jaundice Outcome: Often requires gallbladder removal surgery The Side Effects Everyone Gets (But Still Takes the Drug) Nausea: ~50% of users (RAND survey) Diarrhea: ~33% of users Stopped Due to Side Effects: 13% of users Stopped Due to Cost: 14% of users According to the RAND American Life Panel survey of 8,793 Americans, about half of GLP-1 users experienced nausea and roughly one-third experienced diarrhea
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For example, individuals with CPT deficiency may be given carnitine supplements to enhance the transport of fatty acids into mitochondria
A structured, clinician-guided taper when you reach your goal
