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GLP-1 therapies have been shown to relieve the burden on the ER, reduce ER stress, and decrease subsequent hepatocyte apoptosis (Sharma et al., 2011)

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Retatrutide already creates a significant caloric deficit through appetite suppression

The first promotes albumin binding, which slows renal clearance

doi:10.1038/s41591-024-03374-z Borlaug BA, Zile MR, Kramer CM, et al